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Drug Studies in the Elderly Methodological Concerns

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Published by Springer .
Written in English


  • Geriatric medicine,
  • Medical,
  • Medical / Nursing,
  • Chemotherapy,
  • Pharmacology,
  • Medical / Geriatrics,
  • Gerontology,
  • Age factors,
  • Drugs,
  • Geriatric Pharmacology,
  • Metabolism,
  • Methodology,
  • Research,
  • Testing

Book details:

Edition Notes

ContributionsN.R. Cutler (Editor), P.K. Narang (Editor)
The Physical Object
Number of Pages464
ID Numbers
Open LibraryOL10323737M
ISBN 100306423111
ISBN 109780306423116

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There are a few studies concerning the drug use in elderly. The prevalance of the chronic disease and multiple drug use increase in the older population. The aim of this study was to evaluate and. the elderly suffer two to five times the frequency of adverse drug reactions as occur among younger people, and some 10% of hospital admissions for seniors are due to such reactions. Risk Factors: Prescribing practices are part of this problem. A recent report on a national study found that nearly. Serum albumin decreases and alpha 1-acid glycoprotein increases with age, but the clinical effect of these changes on serum drug binding varies with different drugs. In patients with an acute disorder or malnutrition, rapid reductions in serum albumin may enhance drug effects because serum concentrations of unbound (free) drug may increase. E7 Studies in Support of Special that apply in the design and conduct of clinical trials of medicines that are likely to have significant use in the elderly. Since the E7 guidance was made.

Age may increase sensitivity to the anticoagulant effect of l dosing and routine monitoring can largely overcome the increased risk of bleeding in older adults taking , because drug interactions with warfarin are common, closer monitoring is necessary when new drugs are added or old ones are stopped; computerized drug interaction programs should be consulted if. Appendix G. Drug infusion rates Appendix H. Identifying life-threatening adverse reactions Appendix I. Potentially inappropriate drugs for elderly patients Appendix J. Hazardous drugs Appendix K. Drugs that prolong the QT interval Appendix L. Most commonly used drugs . generally be avoided in all elderly, used with caution, or used with caution or avoided in certain elderly.1 There is also a list of potentially harmful drug-drug interactions in seniors, as well as a list of medications that may need to be avoided or have their dosage reduced based on renal function.1 This information. Whereas recent approaches have recommended to remove particular drugs from the medication regimen to avoid adverse effects, Drug Therapy for the Elderly underlines both indispensable and dispensable elements of drug treatment in order to provide an overall assessment of drugs suitable for the aged. In view of the multimorbidity and polypharmacy Reviews: 1.

  In connection with the idea that drug-induced disease begins to get more common before it is interesting to note that in a number of studies comparing the way “older” people clear drugs out of the body with the way younger people do, the definition of older is ab and younger is . Hanlon JT, Semla TP, Schmader KE, et al: Alternative medications for medications in the use of high-risk medications in the elderly and potentially harmful drug-disease interactions in the elderly quality measures. J Am Geriatr Soc 63(12): e8-e18, doi: /jgs Drug-related problems in the elderly is intended to serve as a source of information and clinical support in geriatric pharmacotherapy for students as well as all health care professionals, e.g. physicians, nurses and pharmacists. Pharmacotherapy is of great importance to all mankind. Drugs are. Medication errors and adverse drug events are common in older adults, but locating literature addressing these issues is often challenging. The objective of this article was to summarize recent studies addressing medication errors and adverse drug events in a single location to improve accessibility for individuals working with older adults.